SDHB and hereditary clear cell renal cell carcinoma: Germline defects in SDH, particularly in SDHA and SDHB, have been detected in several tumor types, including pheochromocytomas (Van Nederveen et al. 2009;Astuti et al. 2001), paragangliomas (Van Nederveen et al. 2009; Astuti et al. 2001; Baysal 2003;Burnichon et al. 2010), GISTs (Gaal et al. 2011;Gill et al. 2010b; Gill et al. 2011a), and renal cell carcinomas (Gill et al. 2011b).