PCLAF and necrotizing enterocolitis: Regardless of the underlying risk factors, the endogenous inflammatory mediators such as interleukins, platelet activating factor (PAF) and nitric oxide (NO) have been implicated in the final common pathogenesis of NEC Edelson et al. (1999; Ewer 2002; Muguruma et al. 1997; Caplan et al. 2005).