SIRT1 and Parkinson disease: Additionally, SIRT1 overexpression (Wareski et al., 2009) or activation by resveratrol (Okawara et al., 2007; Chao et al., 2008; Albani et al., 2009) slows neuronal death as well as neurodegeneration in PD models both in vivo and in vitro (Donmez et al., 2012), indicating a neuroprotective role of SIRT1 against PD.