In a study with SIRT1 transgenic mice, where human SIRT1 was overexpressed under the control of rat neuron-specific enolase promoter, no neuroprotection was observed against stroke as SIRT1 and wild-type mice demonstrated almost indistinguishable infarct volumes and neurological deficiency scores (Kakefuda et al., 2009). This evidence concerns the gene SIRT1 and Stroke.