MED1 and Familial prostate cancer: CCAR1 is recruited to the enhancers of endogenous AR target genes (Figure 1 and Supplementary Figures S3 and S11); and depletion of CCAR1 caused reduction in DHT-induced expression of a subset of endogenous AR target genes (Figure 2 and Supplementary Figures S4 and S5), significantly reduced hormone-dependent recruitment of AR, MED1 and Pol II to the enhancers (Figure 4 and Supplementary Figure S11) and attenuated hormone-dependent growth of prostate cancer cells (Figure 3A and Supplementary Figure S5C).