DLEU2 and B-cell chronic lymphocytic leukemia: Deleted in leukemia 1 (DLEU1) and 2 (DLEU2) are two genes transcribed head to head in a 30-kb region located in the long arm of chrormosome 13 (13q14), which is lost in more than 50% of patients with CLL and that predicts a poor prognosis [192].