DLEU2 and B-cell chronic lymphocytic leukemia: However the knockout model of DLEU2, which includes deletion of hsa-miR-16-1 and hsa-miR-15a as well, shows a more aggressive phenotype than the hsa-miR-16-1/hsa-miR-15a 6 knockout model alone, suggesting that DLEU2 can participate in CLL development on its own.