Genome-wide association studies revealed that ANRIL is located in a genetic susceptibility locus (9p21) associated with several diseases, including coronary artery disease (CAD), atherosclerosis, intracranial aneurysm, type 2 diabetes, and several cancers, such as glioma, basal cell carcinoma, nasopharyngeal carcinoma, and breast cancer [179]. Here, CDKN2B-AS1 is linked to coronary artery disorder.