Consistent with this, suggestive opposing signals were seen at a single marker proximal to interleukin 28 receptor alpha (interferon, lambda receptor, IL28RA); a gene previously implicated in viral infection and resolution (45), and at a missense mutation in TRAF3IP2; an evolutionarily conserved component of the host antiviral signalling pathway (46). The gene discussed is TRAF3IP2; the disease is viral infectious disease.