While cyclin D1/CDK4 specifically mediates centrosome amplification triggered by H-RasG12D, H-RasG12D&c-Myc [97], and in HER2+ breast cancer cells [76], silencing of cyclin E or CDK2 have no impact on centrosome amplification in the HER2/Ras systems. This evidence concerns the gene CCND1 and breast cancer.