Even the epithelioid angiosarcoma may be similar to the PES, in fact immunohistochemically the tumor is positive for the pan-cytokeratin, p63, cytokeratin18, Vimentin and vascular markers CD31, and is negative for CD34, cytokeratin5/6, cytokeratin7, cytokeratin20, CD68, CD30, S-100, HMB45, desmin, α-SMA and CD45[33]. This evidence concerns the gene PMEL and neoplasm.