This deconvolution approach represents the most useful noninvasive method of quantifying pre-hepatic insulin secretion and has been used in clinical research[9], but not yet been established, validated and used in an NHP species over a range of different β-cell function conditions, including normal, prediabetes with disturbed metabolism, and overt T2D, to quantify alterations in insulin secretion. This evidence concerns the gene INS and prediabetes syndrome.