However, there was no significant difference in glucose-stimulated increase in ISR between the N and DYS groups and a significantly reduced MCRI during GGI in the DYS monkeys, indicating that the exaggerated elevation of insulin and C-peptide concentrations during GGI is predominantly contributed by a diminished hepatic insulin clearance, probably a result of hyperinsulinemia-induced saturation of the hepatic insulin extraction capacity. This evidence concerns the gene INS and Hyperinsulinemia.