Intriguingly, these events were paralleled by suppressing the expression and function of mTOR, but do not influence the anti-apoptotic family members such as Bcl-2, Bcl-XL and Mcl-1, suggesting that AZD8055 and radiation synergistically induced cell apoptosis through mTOR related signaling pathways but not Bcl-2 family in pancreatic cancer cells. Here, BCL2L1 is linked to familial pancreatic carcinoma.