From the univariate analysis; male sex, plasma HIV-1 RNA level > 5 log 10 copies/ml and metabolic syndrome at baseline visit, high BMI ≥ 23 kg/m2 and abnormal HDL cholesterol at time of ALT elevation and treatment experience with NNRTI plus boosted PI were selected to the final model of multivariate analysis (Table 6). This evidence concerns the gene GPT and metabolic syndrome.