RBFOX3 and holoprosencephaly: An example is the displacement of NeuN-reactive large neurones in the superficial, rather than the deep, part of the cortical plate in holoprosencephaly [209], suggesting that the inside-out pattern of distribution of the waves of radial migration did not occur because neurones in the deep layers normally show NeuN expression sooner than the superficial layers, as illustrated in Figure 1A, B; this inversion also is seen in the abnormal nodular architecture of some cortical dysgenesis patterns (Figure 1F).