ENO2 and Encephalopathy: A second reason that NSE immunoreactivity in tissue sections of brain remains important is that clinicians, including neonatologists, increasingly measure NSE and NNE levels in serum and especially in cerebrospinal fluid (CSF) as a biomarker of “brain damage” in premature and term neonates, as well as older children, who have suffered hypoxic-ischaemic and other encephalopathies [81, 80, 82, 83, 84].