CD28 and Ito hypomelanosis: B-cell counts (D1: p = 0.048, D3: p = 0.043), CD3+ T-cell counts (D1: p = 0.018, D3: p = 0.001, and D10: p = 0.001, respectively), CD8+ T-cell counts (D1: p = 0.002, D3: p < 0.001, and D10: p < 0.001, respectively), CD28+CD4+ T-cell counts (D1: p = 0.028, D3: p = 0.049, and D10: p = 0.022, respectively), and CD28+CD8+ T-cell counts (D1: p = 0.003, D3: p < 0.001, and D10: p < 0.001, respectively) were significantly lower in the IPA than the non-IPA group.