We also found that the phosphorylation of pVEGFR2, PI3K and pAKT was attenuated in three colon cancer cells by STB-HO (Figure 5B), demonstrating STB-HO can abrogate the activity of proliferation in cancer cells via suppression of pVEGFR2, PI3K and pAKT. The gene discussed is HMOX1; the disease is malignant colon neoplasm.