Though STB-HO exerted anti-proliferative activity in HCT116, SW620 and HCT15 colorectal cancer cells, HCT116 cells are were more susceptible to STB-HO compared to two other colon cancer cells, since they are positive for transforming growth factor beta 1 (TGF beta 1) and beta 2 (TGF beta 2) expression with a mutation in codon 13 of the ras protooncogene [31]. The gene discussed is TGFB1; the disease is malignant colon neoplasm.