For instances, arsenic trioxide (As2O3) was known to treat breast cancer [22] and colon cancer cells [23,24], selenium (Se) was reported to have antitumor potential in several cancers such as colon [25,26], prostate [27,28], zinc (Zn) was reported to have potential therapeutic for chemoresistant ovarian cancer [29] and also cadmium (Cd) induced mitogenic signaling in breast cancer cell by an ER alpha-dependent mechanism [30]. This evidence concerns the gene ESR1 and breast cancer.