Mineral Mica (STB-HO) showed cytotoxicity in colorectal cancer cells, increased G1 arrest and, reduced VEGF production in HCT116 colorectal cancer cells, attenuated the phosphorylation of VEGFR2 and Akt in HUVECs and suppressed the tumor volume and weight in athymic nude mice inoculated with HCT116 cells. This evidence concerns the gene VEGFA and colorectal cancer.