In our previous study on BRAF mutations using very highly sensitive dual-priming oligonucleotide-PCR and mutant enrichment with 3′-modified oligonucleotide sequencing in 4,585 consecutive cases in fine needle aspiration cytology specimens, BRAF mutation was not significantly associated with pT stage, extrathyroidal extension and lymph node metastasis [12]. This evidence concerns the gene BRAF and metastatic malignant neoplasm in the lymph nodes.