PRKN and Parkinson disease: Highlighting this are genetic studies demonstrating the involvement of genes regulating mitochondrial morphology – MFN2 and GDAP-1 in Charcot-Marie-Tooth type2A, as well as OPA1in Optic Atrophy – and mitochondrial quality control – AFG3L2 in Spinocerebellar Ataxia type 28, parkin and PINK1 in PD – in neurodegenerative disease (16, , , , , , –23).