Previous studies conducted in the rat low-protein model of IUGR, resulted in a reduction of PDX-1 protein expression (Park et al., 2008) as well as a reduction in mRNA expression of Glut2, Hnf4a, Pdx-1, Rfx6, and Ins (Pinney and Simmons, 2010; Sandovici et al., 2011; Rodriguez-Trejo et al., 2012). This evidence concerns the gene INS and fetal growth restriction.