iPLA2 activity is downregulated in some AD patients and this may also contribute to the enrichment in PC(16:0/16:0), PAF(O-16:0/2:0), and lyso-PAF(O-16:0/0:0) detected in some MS datasets (Talbot et al., 2000; Ryan et al., 2009) (Figure 3B, Table S2). This evidence concerns the gene PLA2G6 and Alzheimer disease.