MAPT and Alzheimer disease: Acute intraneuronal accumulation of PC(O-16:0/2:0) but not PAF species with other sn-1 carbon chains initiates an endoplasmic reticulum stress-dependent signaling cascade culminating in the hyperphosphorylation of tau on Alzheimer Disease-specific epitopes by cyclin-dependent kinase 5 (Ryan et al., 2008, 2009).