PSEN1 and memory impairment: Enhancing apolipoprotein E (ApoE)-dependent trafficking of PUFAs from neurons to glia in APP/presenilin 1 (PS1) transgenic mice changes the phospholipid composition of synaptosomes, increases Aβ42 clearance, and reverses learning and memory impairment (Igbavboa et al., 2002; Cramer et al., 2012).