WNK2 and central nervous system cancer: For example, the src-targeted tyrosines 247 and 265 can affect the ability of Cx43 to inhibit proliferation of glioma cells (Herrero-Gonzalez et al., 2010); serines 255, 262, 279, 282 are reported as targets of mitogen-activated protein kinase pathways, and, their phosphorylation allows for platelet-derived growth factor-triggered mitotic stimulation of vascular smooth muscle cells (Johnstone et al., 2012).