Increased concentrations of CRH were found in the cerebrospinal fluid (CSF) of a subset of patients with depression (Nemeroff et al., 1984; Holsboer, 2000) and also a number of endocrine function tests (Holsboer, 2000) were in agreement with elevations of central CRH in many severely depressed patients. The gene discussed is CRH; the disease is depressive disorder.