The homozygosity data for individual II:3 showed multiple homozygous intervals, which included three known retinal degeneration-causative genes: IQ motif containing B1 (IQCB1), rhodopsin (RHO), and PDE6B. WES data revealed a deletion of a C nucleotide at position 1417 of PDE6B cDNA (GenBank accession number NM_000283), located in exon 11 (c.1417delC; Figure 1B). The gene discussed is PDE6B; the disease is retinal degeneration.