Here, we report a rare case of a nuclear consanguineous family in which three of four siblings are affected with RP due to mutations of myosin VIIA (MYO7A, underlying USH1) [6] and/or phosphodiesterase 6B, cyclic guanosine monophosphate-specific, rod, beta (PDE6B, underlying nonsyndromic RP) [7]. This evidence concerns the gene PDE6B and retinitis pigmentosa 1.