Furthermore, work by Higashimori et al. found that TLR2 deficiency diminishes foam cell accumulation in lesion-prone areas of the aorta of ApoE−/− mice [67] yielding further support to the pathogenic effect of TLR2 in murine models of atherosclerosis by Mullick et al. [62]. The gene discussed is TLR2; the disease is atherosclerosis.