LDLR and atherosclerosis: In a study led by Curtiss et al. that examined the TRIF mutated gene (Lps2) in LDLR−/− mice, the authors found that LDLR−/− mice with lack-of-function mutations in TRIF (Lps2) were significantly protected from atherosclerosis, assessed by heart sinus and aorta lesion size quantifications, where the mice displayed fewer observed lesional macrophages [68].