Tzelepi and colleagues have evaluated the protein expression of different Hh components (Shh, Ptch, Smo and Gli1) in tissue microarrays constructed with 141 prostatic tumor tissue samples, 119 adjacent non-neoplastic peripheral zone (PZ) tissue samples and 53 bone marrow PCa metastases tissue samples. The gene discussed is PTCH1; the disease is posterior cortical atrophy.