A study by Mimeault et al. demonstrated that co-targeting of the Hh and EGFR pathway in combination with chemotherapeutic agents results in increased anti-proliferative, anti-invasive and apoptotic effects on different metastatic PCa cell lines compared to the single or two-drug strategies, indicating that targeting both signaling pathways could enhance chemosensitivity [137]. Here, EGFR is linked to posterior cortical atrophy.