GNMT and neoplasm: This pathway also includes an oxidative phase, which removes the methyl group from sarcosine to create glycine and an active one-carbon unit by sarcosine dehydrogenase (SARDH), a mitochondrial flavoprotein [51] which, in a study by Montrose et al., was observed within the tumour tissue with GNMT and other enzymes and can explain the increases in sarcosine levels [48].