In a previous study, we showed that mice lacking functional NF-κB signaling in astrocytes (GFAP-IκBα-dn transgenic mice) recover better following moderate spinal cord contusion, with a significant improvement in locomotor function that correlates with a smaller lesion area and a larger area of white matter preservation compared to injured WT LM [12]. The gene discussed is GFAP; the disease is spinal cord injury.