EEF1A2 and breast neoplasm: We were interested in this question because of several lines of evidence implicating a role for PI4KIII β in breast cancer and filopodia production: it is activated by eEF1A2 (eukaryotic elongation factor 1 alpha 2) [14], which is amplified in approximately two-thirds of breast tumours [15,16]; it was recently identified as a putative breast cancer driver gene, in a large-scale copy number and gene expression analysis of 2000 breast tumours [17]; and ectopic expression of PI4KIII β in fibroblast cells increases filopodia number and length [5,14].