This was the most robustly associated gene in the study by Shah et al. The role of IGF1 signalling in cardiac hypertrophy is well established [51,52] and the SNP lies immediately adjacent to a regulatory region recently identified by the ENCODE as being marked as transcriptional active in muscle cells, by Histone acetylation and DNAse 1 sensitivity [51]. Here, IGF1 is linked to cardiac hypertrophy.