Five major genes are linked to hypertension-related functions, of which CGREF1 and JPH1 are involved in calcium ion binding/transport, LPHN3 is in G-protein-coupled receptor signaling pathways, TNIK is in Wnt receptor signaling pathway, nervous system development and response to stress, and GRID2 is in glutamate signaling pathway, neuroactive ligand-receptor interaction and long-term depression. This evidence concerns the gene CGREF1 and hypertensive disorder.