Four major genes are associated with diseases frequently associated with hypertension, of which TMEM16A (also known as ANO1) is with pulmonary hypertension in rat [38], NINJ2 is with stroke [39], AKAP12 is with chronic kidney disease in Japanese individuals [40], and LTBP1 is with abdominal aortic aneurysm [41] and coronary atherosclerotic plaques [42]. This evidence concerns the gene AKAP12 and hypertensive disorder.