SPON2 and liver cancer: In addition to crosstalk of TH signaling with other important pathways, T3 regulates metabolism-related genes or ECM proteins that influence liver cancer progression, such as Aldo-keto reductase family 1, member B1 (AKR1B1), Methionine Adenosyltransferase Ia (MAT1A), and Spondin 2 [26, 161, 162].