By contrast, T3 not only reduced the size of hepatic preneoplastic nodules of rats suffering from HCC, it also suppressed aberrant cellular growth by controlling the expression of cell-cycle regulators, such as PTTG1, ppRb, CDK2, and cyclin E in hepatoma cell lines [24, 125, 160]. The gene discussed is CDK2; the disease is hepatocellular carcinoma.