PLAU and ovarian carcinoma: uPAR is highly expressed in multiple types of cancers, including liver, colon, breast, lung, stomach, and ovarian cancers [136], and binds to uPA, pro-uPA, and the ECM protein, vitronectin, with high affinity; this leads to activation of the serine protease, uPA, thereby regulating proteolytic activity at the cell surface [137].