INS and type 2 diabetes mellitus: Seven diabetes-related serum miRNAs: miR-9, miR-29a, miR-30d, miR-34a, miR-124a, miR-146a, and miR-375 [73], had been reported previously as key gene regulators involved in the regulation of insulin gene expression, insulin secretion [41, 43, 48], insulin signaling in target tissues [74], and free fatty acid (FFA) mediated β-cell dysfunction [75], all of which are closely related to the pathogenesis of T2D.