MYBL2 and myelodysplastic syndrome: To determine which MDS patients with a normal karyotype have an ‘MYBL2-low’ expression signature, we first analyzed the expression levels of MYBL2-regulated genes in the CD34+ cells from our 18 normal-karyotype MDS cases, using a k-nearest neighbor (KNN) classifier and Euclidean distance (k = 3) to predict the class label by a majority vote.