MYBL2 and myelodysplastic syndrome: If sub-haploinsufficient decreases in MYBL2 dosage contribute to MDS pathogenesis, a technique such as RNAi knockdown with a series of shRNA hairpins of graded potencies should provide an experimental model that can be used to demonstrate a clonal advantage within hematopoietic progenitor cells and implicate the level of Mybl2 knockdown that produces the maximum effect.