CD34 and myelodysplastic syndrome: We would also stress that in the range of MYBL2 dosage reductions in this study were modeled based on those found in CD34+ cells from MDS clinical samples, in which the reductions of MYBL2 gene dosage were predominately in the range of 20–30% of normal levels, and thus were considerably lower than the 50% predicted by classical haploinsufficiency.