IGHE and asthma: This latter observation may be due to a subgroup effect among the late-onset non-atopic obese asthma phenotype described above, as Dixon et al. [34] demonstrated that obese asthmatics who had a low serum IgE (presumably late-onset of asthma) had improved airway hyperreactivity 12 months after bariatric surgery, but those with elevated serum IgE (presumably early onset of asthma) did not.