Lastly, infection of VSMCs by C. pneumoniae induces the production of IL-6, basic fibroblast growth factor (bFGF), and MMP, via NF-κB activation, contributing to plaque destabilization, and MCP-1 release through toll-like receptor 2 (TLR-2), promoting monocyte migration into intima [77,78]. The gene discussed is FGF2; the disease is infection.