Our results indicate that aPC induces the secretion of cytokines such as TARC(23,24), TECK(25), IL-2(26), TPO(27), BLC(28), PDGF-BB(29), CNTF (ciliary neurotrophic factor)(30), I-TAC(31)and ICAM-3(32)by tumor cells. The gene discussed is ICAM3; the disease is neoplasm.