To underline the significance of sEPCR in tumor behavior and its influence on circulating immune cells, we analyzed the correlation of sEPCR level in plasma with that of immune cells from blood in 33 patients, using antibodies against CD45, CD45ra, CD3, CD4, CD8, CD25, Foxp3, CD294, CD30, CD56, CD161, CD14, CD16, CD20, CD31, Cd133, CD31, CD10, CD146, IL-21, IL-2, TGFβ, IL-17a, IL10, CD94, CD127, ROR-γ, CD127 and CD29. The gene discussed is IL21; the disease is neoplasm.