In a parallel, but different study (unpublished data) using mRNA-gene array (n=1200) and DAVID analysis of results, we showed the activation of innate immune gene family such as Jak-STAT(46)and TOLL-like receptor(47)when the breast cancer MDA-231 cell line was stimulated by activated protein C. These results suggest that plasma aPC/sEPCR can influence plasma cytokine levels in a quantitative and qualitative manner. This evidence concerns the gene PROC and breast carcinoma.