VEGFA and neoplasm: Hypoxia-inducible factor-1 (HIF-1) is a transcriptional factor which consists of two subunits; under hypoxic conditions it may induce transcription of various genes involved in tumor angiogenesis (like vascular endothelial growth factor- VEGF), invasion (metalloproteinases), cell survival (antiapoptotic proteins), and glucose metabolism insulin growth factor receptor activation [12].