Several of these variants (9 for IRS-1: p.Gln655His, p.Asp1014Gly, p.Asp1181His, p.Pro1203Ser; p.Gly40fs, IVS1+4C>T, c.2766G>A, c.3168C>T, c.3618C>T; 4 for IRS-2: pPro710Ser, p.Asp782Asn, pVal798Ile, pGly1230Ser) were identified in CRC cell lines. The gene discussed is IRS2; the disease is colorectal carcinoma.