MAPT and neurodegenerative disease: To the extent that connections with particular properties are concentrated in a single functional network, the nexopathy paradigm would predict that proteinopathies targeting those connections should principally affect that network: this may explain the existence of neurodegenerative diseases (such as those associated with MAPT mutation and TDP-C pathology) that preferentially target the anterior temporal–inferior frontal lobe semantic network [7,18,21,69,74,75].