A previous GWAS analysis of chronic lymphocytic leukemia identified arisk SNP rs13397985 located in intron 1 of SP140. It was proposed that thisGWAS signal SNP affects SP140 gene transcription [42], but a recent replication study indicates that the association of this SNPto SP140 steady state gene expression levels is only marginal (FDR = 0.157after adjusting for multiple testing) [46]. Here, SP140 is linked to B-cell chronic lymphocytic leukemia.