ITPA and hepatitis A virus infection: For example, the SNP rs11697186 located in geneDDRGK1 near the ITPA gene (Inosine TriphosphatePyrophosphohydrolase) was significantly associated with response to hepatitis Ctreatment in a GWAS study, and later was found to be in high LD with SNP rs1127354 onITPA exon 2 by fine mapping [50].