In accordance with these studies, a strong acute inflammatory response characterized by neutrophilic influx, increased cytokine secretion (KC, TNF-α, MIP-2, MIP-1α and MCP1), proinflammatory gene expression (KC, MIP-2 and MMP12) and up-regulated GM-CSF production was observed in the mainstream CS model. Here, CCL2 is linked to Cowden syndrome 1.