Thus, deregulation of the HMT EZH2 (enhancer of zeste homologue 2) [48], responsible for the repressive mark H3K27me3 (histone 3 lysine 27 trymethylated), and of HMT G9a [also known as EHMT2 (histone-lysine N-methyltransferase)] [49], responsible for the repressive mark H3K9me3 (histone 3 lysine 9 trimethylated), leads to altered distribution of the methylation with consequent silencing of tumour suppressor genes. Here, HNMT is linked to neoplasm.