Integrated genomic analysis has identified mutations in distinct types of GBM including (1) TP53 and isocitrate dehydrogenase1 (IDH1) in proneural tumors; (2) NF1in the Mesenchymal subgroup; (3) histone 3.3 in pediatric GBM; and (4) EGFR amplification in classical GBM tumor (1). This evidence concerns the gene EGFR and glioblastoma.