Fisetin, a flavonoid, activates AMPK to induce apoptosis in multiple myeloma cells (85), inhibits PI3K/AKT and mTOR and activates AMPK in non-small cell lung cancer (86), and induces autophagy-mediated cell death by activating AMPK and suppressing mTOR in prostate cancer cells (87). This evidence concerns the gene MTOR and plasma cell myeloma.