Although they were not the top categories, apoptotic pathways, including the activation of pro-apoptotic gene products, response to unfolded proteins, activation of caspase activity, release of cytochrome C from the mitochondria, and induction of apoptosis by extracellular signals were upregulated during the early acute phase, supporting previous in vitro and in vivo observations on cell apoptosis during early days of infection. Here, CYCS is linked to infection.