Several IL-20R1- and IL-10R2 expressing cell types including the colon carcinoma cell lines Colo-205 and LoVo, primary keratinocytes, and the keratinocyte cell line HaCaT react to IL-26 with the tyrosine phosphorylation of signal transducers and activators of transcription (STAT) 1 and 3 in a dose- and time-dependent manner [15,29,34]. The gene discussed is IL20RA; the disease is colon carcinoma.