While it proved technically unfeasible to determine the responsible factor for the observed CD14+ subset skewing in cancer-conditioned explants (due to the limited size of mastectomy-derived skin samples), testing of a panel of six well-known cancer-associated suppressive cytokines (as well as PGE2, data not shown) clearly pointed to a unique role for IL-10 in this respect (see Fig. 1F). Here, IL10 is linked to cancer.