For another example, FBP1, an estrogen signaling responsive gene that encodes the enzyme catalyzing the reverse reaction of PFKP[58], [59], was upregulated in the ER+ cancers, which could elevate the activity of the oxidative branch of the pentose phosphate pathway and thereby contribute to cancers [60], [61] (Figure 2). The gene discussed is FBP1; the disease is cancer.