In active TB patients there was a rapid decline in the level of MD-2 compared to baseline, significant already after 2 weeks of treatment (2300 ng/ml [2100–4300], p = 0.011), and still significant at week 8 (2125 ng/ml [2000–3450], p = 0.028) and week 24 (1895 ng/ml [1560–2200], (p = 0.001). This evidence concerns the gene LY96 and tuberculosis.