AKT1 and early-onset autosomal dominant Alzheimer disease: Previous studies have shown the effect of PI3K/Akt pathway in stimulating LTP [19] and lipoic acid has been shown to reverse the age-related decrease of LTP and memory deficits in aged rats [55,56], to reduce the hippocampal memory deficits in the Tg2576 model of Alzheimer’s disease [57], and to stabilize cognitive functions in patients afflicted with moderate Alzheimer’s disease [58].