Among the identified GASI genes in this analysis that have been implicated in AD or late-onset Alzheimer disease (LOAD) include ApoE[46], [47], Mapt[48], Igf1r (insulin-like growth factor 1 receptor) [49], Clu[50], [51], Picalm (phosphatidylinositol binding clathrin assembly protein) [50], [51], Cdk5r1(cyclin-dependent kinase 5, regulatory subunit 1, p35) [52], and Ide (Insulin degrading enzyme) [53]. The gene discussed is PICALM; the disease is late-onset Alzheimers disease.