In Andersen’s Syndrome, the loss of function mutations of KCNJ2 gene encoding for the Kir2.1 is associated with arrhythmias, muscle weakness and skeletal muscle dysmorphisms as demonstrated in the Kir2.1 knockout mice, which exhibits a narrow maxilla and complete cleft of the secondary palate that may mimic the facial dysmorphology, observed in humans [9,16]. The gene discussed is KCNJ2; the disease is Cardiodysrhythmic potassium-sensitive periodic paralysis.